© UWSSA 2007 all rights reserved
a kymdunbar.com design
All photos & text are the property of UWSSA. Contact us for permission to use anything on this website. We are not affiliated with any other orgsnisation unless specifically stated.
Problem Drugs
There are many different types of drugs reported to cause problems in the working type breed, from over-the-counter antidiarrheal agents like ImodiumŪ to antiparasitic and chemotherapy agents. This list may grow as worldwide research progresses:
õ Acepromazine (tranquilliser)
õ Butorphanol (pain control)
õ Cyclosporin (immunosuppressant)
õ Digoxin (heart drug) Doxorubicin (cancer drug)
õ Ivermectin (antiparasitic)
õ Loperamide (antidiarrheal)
õ Vinblastine (cancer drug)
There are many different types of drugs reported to cause problems in the working type breed, from over-the-counter antidiarrheal agents like ImodiumŪ to antiparasitic and chemotherapy agents. This list may grow as worldwide research progresses:
õ Acepromazine (tranquilliser)
õ Butorphanol (pain control)
õ Cyclosporin (immunosuppressant)
õ Digoxin (heart drug) Doxorubicin (cancer drug)
õ Ivermectin (antiparasitic)
õ Loperamide (antidiarrheal)
õ Vinblastine (cancer drug)
õ Vincristine (cancer drug)
The following drugs may potentially cause problems when given to dogs that have the mutation. Biochemical studies have shown that this gene has the potential to act on over 50 different drugs.
õ Ondansetron
õ Domperidone
õ Paclitaxel
õ Mitoxantrone
õ Etoposide
õ Rifampicin
õ Quinidine
õ Morphine
The following drugs may potentially cause problems when given to dogs that have the mutation. Biochemical studies have shown that this gene has the potential to act on over 50 different drugs.
õ Ondansetron
õ Domperidone
õ Paclitaxel
õ Mitoxantrone
õ Etoposide
õ Rifampicin
õ Quinidine
õ Morphine
DNA Testing
You can have your dogs DNA tested instead of avoiding drugs like Ivermectin in known susceptible breeds.
Veterinarians can now determine if the dog has a normal MDR1 gene, in which case the drug can be safely used, or the dog is affected, in which case an alternate treatment would be advised.
Breeders now can use this information to detect carriers and eliminate this disease by planned breeding.
For more information click here
You can have your dogs DNA tested instead of avoiding drugs like Ivermectin in known susceptible breeds.
Veterinarians can now determine if the dog has a normal MDR1 gene, in which case the drug can be safely used, or the dog is affected, in which case an alternate treatment would be advised.
Breeders now can use this information to detect carriers and eliminate this disease by planned breeding.
For more information click here
The information used on this page has been sourced from Gribbles Pathology and Procdeedings of the National Academy of Sciences Both these websites have lots of interesting information & are worth visitng.
What is it?
A mutation in the canine multidrug resistance gene, MDR1, has previously been associated with drug sensitivities in some working dog lines.
Collies and related breeds can have adverse reactions to drugs such as ivermectin, loperamide (ImodiumŪ), and others. It was previously unknown why some individual dogs were sensitive and others were not. Advances in molecular biology at the Veterinary Clinical Pharmacology Laboratory at Washington State University's College of Veterinary Medicine have led to the discovery of the cause of multi-drug sensitivity in affected dogs.
The problem is a mutation in the multi-drug resistance gene (MDR1). This gene encodes a protein, P-glycoprotein, that is responsible for pumping many drugs and other toxins out of the brain.
Dogs with the mutant gene can not pump some drugs out of the brain as a normal dog would, which may result in abnormal neurologic signs. This results in elevated plasma drug levels and an increased tendency to toxicity.
The result may be an illness requiring an extended hospital stay or even death.
Your dog may become severely ill in reaction to some drugs, or even die, if it has MDR-1.
A mutation in the canine multidrug resistance gene, MDR1, has previously been associated with drug sensitivities in some working dog lines.
Collies and related breeds can have adverse reactions to drugs such as ivermectin, loperamide (ImodiumŪ), and others. It was previously unknown why some individual dogs were sensitive and others were not. Advances in molecular biology at the Veterinary Clinical Pharmacology Laboratory at Washington State University's College of Veterinary Medicine have led to the discovery of the cause of multi-drug sensitivity in affected dogs.
The problem is a mutation in the multi-drug resistance gene (MDR1). This gene encodes a protein, P-glycoprotein, that is responsible for pumping many drugs and other toxins out of the brain.
Dogs with the mutant gene can not pump some drugs out of the brain as a normal dog would, which may result in abnormal neurologic signs. This results in elevated plasma drug levels and an increased tendency to toxicity.
The result may be an illness requiring an extended hospital stay or even death.
Your dog may become severely ill in reaction to some drugs, or even die, if it has MDR-1.
Dogs shown on the health pages do no have any diseases to our knowledge. They are purely to llustrate healthy dogs and puppies.
How MDR1 Could Affect Your White Shepherd
Main Menu
Articles
Affected Breeds
The MDR1 mutation has been found in Collies, Shetland Sheepdogs (Shelties). Australian Shepherds, Old English Sheepdogs, German Shepherds, Long-haired Whippets, Silken Windhounds, and a variety of mixed breed dogs.
The only way to know if your dog has the mutant MDR1 gene is to have the it tested.
Find out more here
The MDR1 mutation has been found in Collies, Shetland Sheepdogs (Shelties). Australian Shepherds, Old English Sheepdogs, German Shepherds, Long-haired Whippets, Silken Windhounds, and a variety of mixed breed dogs.
The only way to know if your dog has the mutant MDR1 gene is to have the it tested.
Find out more here
